Genes asociados a virulencia y patogenicidad de Rickettsia rickettsii: Una revisión sistemática

Me Lin Cortés Sánchez; Florinda Jiménez Vega; Angélica María Escárcega Ávila

doi:10.19136/hs.a24n3.6066

Authors

Mei Lin Cortés Sánchez Universidad Autónoma de Ciudad Juárez
Florinda Jiménez Vega Universidad Autónoma de Ciudad Juárez
Angélica María Escárcega Ávila Universidad Autónoma de Ciudad Juárez

DOI:

https://doi.org/10.19136/hs.a24n3.6066

Abstract

Objective: To review recent literature on the function of genes associated with virulence and pathogenicity in Rickettsia rickettsii.

Materials and Methods: This systematic review followed the PRISMA 2020 guidelines for systematic reviews. Searches were conducted in Google Scholar and PubMed (2015–2025) using keywords and Boolean operators related to the topic.

Results: A total of 5,026 articles were identified. Ultimately, 50 were selected for the preparation of this review. From these, information was obtained regarding the relevance of virulence-associated genes (Adr1, Adr2, RARP2, RapL). Concerning genes associated with bacterial pathogenicity, OmpA, OmpB, Sca2, Sca4, tlyA, tlyC, pld, RLip, and RickA were reported. These genes are necessary for cell interaction, adhesion, and invasion, as well as immune system evasion.

Conclusions: Rickettsia rickettsii is a pathogen of public health importance globally and in Mexico. Therefore, key bacterial genes such as Sca2, Sca4, tlyA, tlyC, RARP2, RapL, Adr1, Adr2, pld, OmpA, and OmpB that influence host interaction and immune evasion were analyzed. However, the strains present in Mexico still require in depth study, and strategies for the prevention, control, and treatment of the disease need to be improved.

Keywords: Rickettsia rickettsii; outer membrane proteins; genes; virulence; pathogenicity; surface cell antigens (Sca).

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Author Biographies

Mei Lin Cortés Sánchez, Universidad Autónoma de Ciudad Juárez

Master in Public Health. Student of the PhD program in Chemical Biological Sciences. Autonomous University of Ciudad Juárez. Chihuahua, Mexico.
Florinda Jiménez Vega, Universidad Autónoma de Ciudad Juárez

PhD in Chemical and Biological Sciences. Research Professor of the Department of Chemical-Biological Sciences. Universidad Autónoma de Ciudad Juárez, Chihuahua, Mexico.
Angélica María Escárcega Ávila, Universidad Autónoma de Ciudad Juárez

PhD in Agricultural Sciences. Research Professor of the Department of Veterinary Sciences. Universidad Autónoma de Ciudad Juárez, Chihuahua, Mexico.